In recent years, studies with a varying number of subjects have shown that many indices, such as D-dimer (DD), soluble vascular endothelial growth factor receptor (sFlt) and platelet distribution width (PDW) are ideal indicators for PE. Therefore, coagulative and fibrinolytic status is a good predictor for the onset and clinical degree of PE. The super-hypercoagulable state of women with PE may also lead to systematic disorders of metabolism as well as multiple organ dysfunction and may even threaten maternal and fetal lives. When this balance is upset in PE patients, the bloodstream of the placenta and many organs is blocked by microthrombosis. An appropriate increase in blood coagulation is important for normal pregnant woman to reduce postpartum hemorrhage and to limit other complications. The balance between coagulation and anticoagulation is vital to the regulation of utero-placental circulation and organ perfusion in pregnant woman. In PE patients, the coagulation-fibrinolytic system is thought to be one of the most seriously affected systems by maternal inflammatory reactions and immune dysfunction. It is necessary to predict the severity of PE for rational gestational management. PE can be classified into two degrees, mild PE (mPE) and severe PE (sPE), and there are different treatments and clinical outcomes for each degree.
Therefore, a reliable predictor for PE would play an important role in early prevention and intervention. To date, there is no effective treatment for PE in addition to the termination of pregnancy. The abnormal invasion of placenta and the release of placenta-derived adverse factors during the first trimester is thought to be the main cause of the extensive damage to the maternal endothelium and systemic inflammatory response involving many systems and organs in late pregnancy. The pathogenesis of PE remains unknown, and the many theories related to the etiology of PE pose great challenges for future investigation. Furthermore, PE has high morbidity and mortality rates. PE is characterized by hypertension (blood pressure ≧140/90 mmHg), proteinuria (≧0.3 g/d), edema and other symptoms and may begin as early as the 20th gestational week and last for 6 weeks after delivery. Preeclampsia (PE) is an intractable obstetric disorder that affects 6–8% of pregnancies worldwide. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Anonymized data sets may be requested from the corresponding author.įunding: This work was supported by a grant of the National Natural Foundation of China (81170576, 81401224). Ethical restrictions prohibit public sharing of data. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. Received: JAccepted: NovemPublished: December 2, 2014Ĭopyright: © 2014 Han et al. PLoS ONE 9(12):Įditor: Sinuhe Hahn, University Hospital Basel, Switzerland (2014) Blood Coagulation Parameters and Platelet Indices: Changes in Normal and Preeclamptic Pregnancies and Predictive Values for Preeclampsia.
Citation: Han L, Liu X, Li H, Zou J, Yang Z, Han J, et al.